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Search Results for " toxin ii "

9

抑制剂 & 化合物

1

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T29804	AK-Toxin II
	AK-Toxin II is a host-specific toxin to Japanese white pear.
T29926	AM Toxin II
	AM Toxin II is a Cyclic tetradepsipeptide isolated from Alternaria mali.
T80456	BDS-II	Sodium Channel	Membrane transporter/Ion channel
	BDS-II为含43个氨基酸的肽类毒素，作用为选择性抑制Kv3.4通道。
T13540	alpha-Amanitin α-Amanitin,α-Amatoxin	Others	Others
	alpha-Amanitin is the principal toxin of poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
T80162	Aah II	Sodium Channel	Membrane transporter/Ion channel
	Aah II为一种从蝎Androctonus australis毒液中提取的钠通道调节剂。
T13474	β-Amanitin	Others	Others
	β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom, and inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis.
T80184	GsAF-II	Sodium Channel	Membrane transporter/Ion channel
	GsAF-II，一种肽毒素，能电压依赖性阻断hERG1亚型钾通道，并对Nav1.x亚型钠离子通道展现阻断效应。
T80039	ATX-II	Sodium Channel	Membrane transporter/Ion channel
	ATX-II为特定Na+通道调节剂，源自海葵(Anemonia sulcata)毒液。该化合物会使细胞培养物对Na+Halothane、Caffeine及Ryanodine敏感，并可诱发肺静脉心律失常及心房颤动。
T82936	ATX-II TFA	Sodium Channel	Membrane transporter/Ion channel
	ATX-II TFA为源自海葵(Anemonia sulcata)毒素的特定Na+通道调节剂，能使细胞培养物对Na+、Halothane、Caffeine和Ryanodine敏感，并可诱发肺静脉心律失常和心房颤动。

化合物

Cat.No: T29804

Cat.No: T29926

Cat.No: T80456

Target: Sodium Channel

Cat.No: T13540

Synonym: α-Amanitin,α-Amatoxin

Target: Others

Cat.No: T80162

Target: Sodium Channel

Cat.No: T13474

Target: Others

Cat.No: T80184

Target: Sodium Channel

Cat.No: T80039

Target: Sodium Channel

Cat.No: T82936

Target: Sodium Channel

Cat. No.	Product Name	Target	Signaling Pathways
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...

天然产物

Cat.No: T35750

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00054	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) Toxin II,Neurotoxin II,A...	Androctonus australis	E. coli
	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484.
TMPH-00361	Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) Toxin 2,Beta-mammal toxin Cn2,Toxin	Centruroides noxius	P. pastoris (Yeast)
	Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals. Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.6 kDa and the accession number is P01495.
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) ATX II,Delta-AITX-Avd1c,Toxin II,...	Anemonia sulcata	P. pastoris (Yeast)
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured...
TMPH-03625	Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) Tityustoxin II,TsTX III-8,Tox...	Tityus serrulatus	Baculovirus Insect Cells
	Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410.
TMPH-03626	Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) Toxin II-11,Beta-like toxin Ts1,T...	Tityus serrulatus	Baculovirus Insect Cells
	Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P15226.
TMPH-03627	Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) Ts VII,Beta-like toxin Ts1,Toxin ...	Tityus serrulatus	E. coli
	Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.3 kDa and the accession number is P15226.
TMPY-02447	Shiga toxin II subunit B Protein, E. coli, Recombinant (His)	E. coli	E. coli
	E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregativ...
TMPH-03001	MT2731 Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	P. pastoris (Yeast)
	Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin MT2730. MT2731 Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.7 kDa and the accession number is P9WJ10.
TMPH-00783	YafQ Protein, Haemophilus influenzae, Recombinant (His & Myc)	Haemophilus influenzae	E. coli
	Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB. YafQ Protein, Haemophilus influenzae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 19.4 kDa and the accession number is P44041.
TMPH-03586	Toxin zeta Protein, S. agalactiae, Recombinant (His)	Streptococcus agalactiae	P. pastoris (Yeast)
	Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Phosphorylation is inhibited by cognate epsilon antitoxin. Part of a postsegregational killing (PSK) system involved in the killing of plasmid-free cells. The zeta toxin induces programmed cell death. Toxin zeta Prote...
TMPH-03565	MazF Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	E. coli
	Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.4 kDa and the accession...
TMPH-03624	Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc)	Tityus bahiensis	E. coli
	Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.0 kDa and the accession number is P...
TMPH-03582	MazF Protein, S. epidermidis, Recombinant (His)	Staphylococcus epidermidis	E. coli
	Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.0 kDa and the acce...
TMPH-03623	Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc)	Tityus bahiensis	Baculovirus Insect Cells
	Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P60276.

重组蛋白

AaH II Protein, Androctonus australis, Recombinant (His & SUMO)

Cat.No: TMPH-00054

Species: Androctonus australis

Expression System: E. coli

Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His)

Cat.No: TMPH-00361

Species: Centruroides noxius

Expression System: P. pastoris (Yeast)

Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Cat.No: TMPH-00056

Species: Anemonia sulcata

Expression System: P. pastoris (Yeast)

Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc)

Cat.No: TMPH-03625

Species: Tityus serrulatus

Expression System: Baculovirus Insect Cells

Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc)

Cat.No: TMPH-03626

Species: Tityus serrulatus

Expression System: Baculovirus Insect Cells

Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03627

Species: Tityus serrulatus

Expression System: E. coli

Shiga toxin II subunit B Protein, E. coli, Recombinant (His)

Cat.No: TMPY-02447

Species: E. coli

Expression System: E. coli

MT2731 Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03001

Species: Mycobacterium tuberculosis

Expression System: P. pastoris (Yeast)

YafQ Protein, Haemophilus influenzae, Recombinant (His & Myc)

Cat.No: TMPH-00783

Species: Haemophilus influenzae

Expression System: E. coli

Toxin zeta Protein, S. agalactiae, Recombinant (His)

Cat.No: TMPH-03586

Species: Streptococcus agalactiae

Expression System: P. pastoris (Yeast)

MazF Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03565

Species: Staphylococcus aureus

Expression System: E. coli

Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03624

Species: Tityus bahiensis

Expression System: E. coli

MazF Protein, S. epidermidis, Recombinant (His)

Cat.No: TMPH-03582

Species: Staphylococcus epidermidis

Expression System: E. coli

Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc)

Cat.No: TMPH-03623

Species: Tityus bahiensis

Expression System: Baculovirus Insect Cells

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